
Cyclosporin H
CAS No. 83602-39-5
Cyclosporin H ( —— )
产品货号. M27415 CAS No. 83602-39-5
环孢素 H (CsH) 是一种 FPR1 特异性抑制剂,可抑制 ALI 模型中的肺部炎症。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2252 | 有现货 |
![]() ![]() |
10MG | ¥3337 | 有现货 |
![]() ![]() |
25MG | ¥5557 | 有现货 |
![]() ![]() |
50MG | ¥7914 | 有现货 |
![]() ![]() |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Cyclosporin H
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述环孢素 H (CsH) 是一种 FPR1 特异性抑制剂,可抑制 ALI 模型中的肺部炎症。
-
产品描述Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosporin H is a viral transduction enhancer which increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). When combined with Rapamycin or Prostaglandin E2 Cyclosporin H displays an additive effect. Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.(In Vitro):Cyclosporin H is a potent inhibitor of FMLP-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibited FMLP binding in HL-60 membranes with a Ki (inhibition constant) of 0.10 μM. Cyclosporin H inhibited activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a Ki of 0.79 μM. Cyclosporin H inhibited the stimulatory effects of FMLP on cytosolic Ca2+ concentration ([Ca2+]i), O2- formation, and beta-glucuronidase release with Ki values of 0.08, 0.24, and 0.45 μM, respectively.(In Vivo):Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel).
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体AXL
-
研究领域——
-
适应症——
化学信息
-
CAS Number83602-39-5
-
分子量1202.61
-
分子式C62H111N11O12
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (83.15 mM)
-
SMILESCN(C(C(CC(C)C)N(C)C(C(C)NC(C(C)NC(C(CC(C)C)N(C)C(C(C(C)C)NC(C(N1C)CC(C)C)=O)=O)=O)=O)=O)=O)C(CC(C)C)C(N(C)C(C(C)C)C(N(C)C(C(O)C(C)C/C=C/C)C(NC(CC)C(N(C)CC1=O)=O)=O)=O)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Jimbo T, et, al. DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model. Oncotarget. 2019 Aug 27;10(50):5152-5167.
产品手册




关联产品
-
Gadoteridol
钆苷用于中枢神经系统成像,用于钆基 MRI 造影剂。
-
Isorhyncophylline
异钩藤碱和钩藤碱能直接抑制多种激动剂引起的大鼠小血管的收缩反应,也能抑制血管紧张素Ⅱ的高血压作用。
-
Sulfo-SANPAH Crossli...
Sulfo-SANPAH 交联剂是一种水溶性同双功能蛋白质交联剂。